Abstract 15443: Unexpected Role of PCSK9 in Human Pluripotent Stem Cells and Their Differentiation

Salam Idriss,Amandine Caillaud,Aurore Girardeau,Benoite Champon,Amandine David,Lucie Arnaud,Matthieu Pichelin,C. Le May,Annik Prat,Anne Camus,Nabil G. Seidah,Bertrand Cariou,Karim Si‐Tayeb

Circulation（2016）

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摘要

Introduction: We previously showed that patient-derived induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes is a relevant model to study the impact of PCSK9 gain-of-function (GO...

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