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Understanding FOXP3: Progress Towards Achieving Transplantation Tolerance

Transplantation(2007)

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摘要
Regulatory T cells (Treg) suppress immune responses, making them an exciting therapeutic target for achieving operational transplant tolerance. Recent observations have identified forkhead box P3 (FOXP3) as a master gene required for the development and function of Treg. Improving our understanding of FOXP3 may facilitate methods for identifying and generating Treg.
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