Vitamin D3 and Markers of Systemic Inflammation in Sarcoidosis (SA)

Background: SA is an inflammatory disease characterized by granulomas that can produce 1.25(OH)2D hormone. Aims: To assess the relationship between vitamin D3 derivatives concentration in serum and inflammatory markers in SA. Material and Methods: In 108 pts (48 women, 60 men; (mean±SD) age 44.3±9.5 yrs, BMI=27.5±4.8) with SA stage I-IV we measured 1.25(OH)2D (pg/m), 25(OH)D (ng/ml) in serum and BALF as well as leukocytes, lymphocyte phenotypes CD4/CD8, alkaline phosphatase (ALP), ACE, D-dimer, fibrinogen, albumin and gammaglobulin, phosphorate in serum and 24h calcium urine excretion. Results: Results are shown below: View this table: There was no other significant correlation between 25OHD or 1.25(OH)2D and other evaluated inflammatory markers. Conclusions: Significant correlations between some inflammatory markers and 25OHD or 1.25(OH)2D concentration in serum may suggests a role of vitamin D3 as an indicators of inflammatory process in SA. Supported by: Polish Ministry of Science grant No 1594/P01/2007/32