Diffusion of intrinsically disordered proteins within viscoelastic membraneless droplets
arxiv(2024)
摘要
In living cells, intrinsically disordered proteins (IDPs), such as FUS and
DDX4, undergo phase separation, forming biomolecular condensates. Using
molecular dynamics simulations, we investigate their behavior in their
respective homogenous droplets. We find that the proteins exhibit transient
subdiffusion due to the viscoelastic nature and confinement effects in the
droplets. The conformation and the instantaneous diffusivity of the proteins
significantly vary between the interior and the interface of the droplet,
resulting in non-Gaussianity in the displacement distributions. This study
highlights key aspects of IDP behavior in biomolecular condensates.
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