Observation of Curative Effects on Blood Purification Combined with Compound Α-Ketonic Acid in Treatment of Uremia

Objective To investigate the clinical curative effects and safety of blood purification combined with Compound α-Ketonic Acid in the treatment of uremia.Methods 80 patients with uremia treated in our hospital from June 2010 to September 2011 were randomly divided into the control group and the treatment group,with 40 patients in each group.The control group was given the blood purification and the other conventional treatment,and the treatment group was given the oral administration of Compound α-Ketonic Acid for one year on the basis of the control group.The blood urea nitrogen(BUN),creatinine(Cr),serum parathyroid hormone(PTH) and serum β2-microglobulin(β2-MG) value changes,the clinical curative effects and the incidence of adverse reactions of the two groups were compared before and after treatment.Results One year after treatment,the BUN,Cr,β2-MG and PTH levels of both groups of patients were significantly reduced(P 0.05),and the reduction degrees of β2-MG and PTH of the treatment group were significantly lower than those of the control group(P 0.05);The obvious effective rate and the total effective rate of the treatment group were significantly higher than those of the control group(P 0.05);the incidence of adverse reactions of the two groups was not significantly different(P 0.05).Conclusion Blood purification combined with Compound α-Ketonic Acid can effectively improve the situation of uremia and has exact clinical curative effects and few side effects,thereby worthy of promotion and application.