The Level of Plasma Total Homocysteine in Type 2 Diabetes and Its Relationship with Macrovascular Diseases

Objective To investigate the plasma total homocystein (stHcy) level, its affecting factors and its relationship with macrovascular diseases in type 2 diabetecs. Methods The stHcy concentration was determined by HPLC method. The intimal medial thikeness(IMT) of common carotid artery was measured by ultrasonography. The clinical and biochemical data were analysed. Results (1)The stHcy level in group of type 2 diabetics was not different from controls ( P 0.5) The age, duration of high blood pressure, serum creatinine, serum uric acid, urine albumin excretive rate,the percentage of patients with IMT 0.8 mm were higher in group of stHcy 15.1 μmol/L. The glumerular filtration rate, glucosyleted hemoglubulin A1c were lower than those in group of stHcy15.1 μmol/L significantly( P 0.05-0.001) (2)The stHtcy level and the percentage of high stHcy in group of thickened IMT was higher than those in normal IMT group and controls( P 0.05～0.001). Multiple linear regresson analysis showed that the stHcy correlated with IMT independently Conclusions The stHcy in diabetic patients was affected by different factors, The high level of stHcy is independent risk factor for macrovascular disease in type 2 DM.