Immune checkpoints are predominantly co-expressed by clonally expanded CD4⁺FoxP3⁺ intratumoral T-cells in primary human cancers

Delphine Bredel, Edi Tihic,Severine Mouraud, Francois-Xavier Danlos,Sandrine Susini,Marine Aglave,Alexia Alfaro, Chifaou Mohamed-Djalim,Mathieu Rouanne,Heloise Halse,Amelie Bigorgne, Stephane Dalle, Lambros Tselikas, Dana M. Hartl, Eric Baudin, Catherine Guettier, Eric Vibert, Olivier Rosmorduc, Caroline Robert, Sophie Ferlicot,Bastien Parier,Laurence Albiges,Vincent Thomas de Montpreville, Benjamin Besse, Olaf Mercier, Caroline Even,Ingrid Breuskin,Marion Classe,Camelia Radulescu, Thierry Lebret, Patricia Pautier, Sebastien Gouy, Jean-Yves Scoazec, Laurence Zitvogel, Aurelien Marabelle,Melodie Bonvalet

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH（2023）

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Cancer,Immunology,Immune checkpoints,T-cells,Immunotherapy,Single-cell RNA-Seq,Flow cytometry,TCR repertoire

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Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers