Attapulgite and Graphene-Based Molecular Imprinted Polymers As 5-FU Delivery Systems for the Treatment of Cervical Cancer

Molecularly imprinted polymers and non-imprinted polymers based on attapulgite and graphene composite were synthesized by coating with copolymer of acrylamide and methyl methacrylate. The adsorption results showed that the molecularly imprinted polymers and non-imprinted polymers could reach the maximum drug loading of 2.4 and 1.6 mg/g, respectively. The in vitro release studies demonstrated that molecularly imprinted polymers and non-imprinted polymers can control the release of 5-fluorouracil and reach maximum release at approximately 48 h. Cytotoxicity analysis showed that 100 mu g/mL of molecularly imprinted polymers loaded with 5-fluorouracil gradually increased the inhibition rate of HeLa with increasing time and approached the maximum inhibition rate of 20 % at 72 h. Molecularly imprinted polymers (MIPs) based on attapulgite and graphene composite were synthesized by coating with copolymer of acrylamide and methyl methacrylate. The addition of 5-FU during the synthesis of MIPs, followed by the removal of the 5-FU template molecules using an elution solution, resulted in the final formation of 5-FU-imprinted cavities, which facilitated the specific recognition of 5-FU.**image