Lentiviral Mediated Delivery of CRISPR/Cas9 Reduces Intraocular Pressure in a Mouse Model of Myocilin Glaucoma.

Shruti V. Patil, Balasankara Reddy Kaipa,Sujata Ranshing,Yogapriya Sundaresan,J. Cameron Millar,Bhavani Nagarajan,Charles Kiehlbauch,Qihong Zhang,Ankur Jain,Charles C. Searby,Todd E. Scheetz,Abbot F. Clark,Val C. Sheffield,Gulab S. Zode

SCIENTIFIC REPORTS（2024）

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Key words

Myocilin-associated Glaucoma,Gene therapy,Genome editing for glaucoma,Trabecular meshwork,Intraocular pressure,Viral vectors,Lentiviral particles,ER stress

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