Research Progress of Drugs for the Treatment of Gout

Gout is directly related to hyperuricemia caused by purine metabolism disorder and/or reduced uric acid excretion, and belongs to the category of metabolic rheumatism. Currently, there are many drugs on the market for the treatment of hyperuricemia and gout, but most of them are chemical synthetic drugs. The main direction of chemical drugs targeted at gout attacks is to inhibit enzyme action or use hormones to relieve pain during gout attacks, and control cytokine/inflammatory cell movement and function to reduce inflammatory response. The treatment in interphase and chronic phase is mainly uric acid lowering treatment. The chemical drugs used to reduce uric acid are mainly divided into three categories: inhibiting the synthesis of uric acid, promoting the excretion of uric acid and promoting the decomposition of uric acid. However, at present, the therapeutic effect of traditional Chinese medicine and biological drugs is gradually obvious. This paper mainly reviews the shortcomings of chemical drugs, traditional Chinese medicine and drug use in the treatment of gout and hyperuricemia, aiming to provide reference for the clinical treatment of hyperuricemia and gout.