Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB

Xiao-xi Zheng, Cheng-feng Zhang, Li-qing Li,Jun-rui Ye,Si-yu Ren,Zhao Zhang,Xin He,Shi-feng Chu,Nai-hong Chen

Brain Research Bulletin（2024）

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摘要

•Celecoxib attenuated depressive symptoms induced by neuroinflammation.•Impaired astrocytic gap junction was improved by celecoxib.•Astrocytic Cx43 was involved in the anti-depressive effect of celecoxib.

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关键词

Major depression disorder,Inflammation,Astrocyte,Gap junction,COX-2,NF-κB

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