Human Ipsc-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy.

Rania Dagher, Aigul Moldobaeva,Elise Gubbins, Sydney Clark,Mia Madel Alfajaro,Craig B. Wilen,Finn Hawkins,Xiaotao Qu,Chia Chien Chiang, Yang Li,Lori Clarke, Yasuhiro Ikeda,Charles Brown,Roland Kolbeck,Qin Ma,Mauricio Rojas,Jonathan L. Koff,Mahboobe Ghaedi

STEM CELLS（2024）

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Key words

COPD,emphysema,disease modeling,induced pluripotent stem cells (iPSC),alveolospheres,type 2 alveolar epithelial cells,mesenchyme crosstalk,SARS-CoV-2,drug testing,therapeutic monoclonal antibodies

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