Biomarker Testing Journey among Patients with Advanced Solid Tumors and Treatment Patterns by Homologous Recombination Repair Status: A Clinico-Genomic Database Study

Changxia Shao,Yixin Ren,Heng Zhou,Liam C. Lee,Cai Chen,Elisha J. Dettman,Razvan Cristescu,Alexander Gozman,Fan Jin,Wei Zhou

Advances in therapy（2024）SCI 3区SCI 4区

Merck & Co.

Cited 0|Views23

Abstract

Defects in the homologous recombination repair (HRR) pathway can include mutations in BRCA1 and BRCA2 (BRCAm) and other HRR genes (HRRm). These mutations are associated with a homologous recombination deficiency (HRD) phenotype. We evaluated testing journey and treatment patterns by BRCAm, HRRm, and HRD status in a real-world dataset. Deidentified data for patients who had undergone comprehensive genomic profiling using FoundationOne®CDx were collected through December 31, 2020, from a real-world multi-tumor clinico-genomic database (CGDB) capturing data from clinics in the United States. Patients eligible for inclusion in this analysis had a confirmed diagnosis with advanced or metastatic disease between January 1, 2018, and December 31, 2019, for 1 of 15 solid tumor types. Objectives were to evaluate patient treatment patterns by BRCAm, HRRm, and HRD status and to describe the timing of when (throughout disease course) comprehensive genomic profiling was performed. Among 9457 patients included in the overall population with evaluable biomarker status, 7856 (83.1

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Key words

BRCA1 and BRCA2 mutation,Homologous recombination deficiency,Homologous recombination repair mutation,Testing patterns,Treatment patterns

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