Exploration of the optimal time to discontinue propranolol treatment in infantile hemangiomas: A prospective study
Journal of the American Academy of Dermatology(2023)
摘要
BACKGROUND:Relapse of infantile hemangiomas (IHs) after withdrawal from propranolol treatment is common. Early withdrawal is believed to increase the risk of relapse.
OBJECTIVE:To determine the optimal time to discontinue propranolol treatment for IHs.
METHODS:A prospective study conducted at a tertiary referral center.
RESULTS:Compared to withdrawal after 1-month maintenance treatment, withdrawal after 3-months maintenance, corresponding achieving maximum regression of IHs, was associated with a lower major relapse rate (P=0.041). The relapse (P=0.055) and adverse event rates (P=0.154) between the two withdrawal modes were not statistically significant. Compared with direct withdrawal, the relapse (P=0.396), major relapse (P=0.963), and adverse event rates (P=0.458) of gradual withdrawal were not statistically different. Patients with/without relapse could be best distinguished according to whether withdrawal followed a 3-months maintenance and age >13 months (AUC=0.603). Patients with/without major relapse could be best distinguished according to whether withdrawal was accompanied by 3-months maintenance (AUC=0.610).
LIMITATIONS:Non-randomization and single-center design.
CONCLUSIONS:The optimal propranolol withdrawal time to avoid relapse is when the patient is aged >13 months and the lesion has maintained for 3 months after reaching maximum regression, while the optimal time to prevent major relapse is after 3 months of maintenance.
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关键词
adverse event,clinical research,infantile hemangioma,propranolol,relapse,withdrawal
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