谷歌浏览器插件
订阅小程序
在清言上使用

Engineering Proteins for PEDOT Dispersions: A New Horizon for Highly Mixed Ionic-Electronic Biocompatible Conducting Materials

SMALL(2024)

引用 0|浏览13
暂无评分
摘要
Poly (3,4-ethylenedioxythiophene) (PEDOT) doped with polystyrene sulfonate (PSS) is the most used conducting polymer from energy to biomedical applications. Despite its exceptional properties, there is a need for developing new materials that can improve some of its inherent limitations, e.g., biocompatibility. In this context, doping PEDOT is propose with a robust recombinant protein with tunable properties, the consensus tetratricopeptide repeated protein (CTPR). The doping consists of an oxidative polymerization, where the PEDOT chains are stabilized by the negative charges of the CTPR protein. CTPR proteins are evaluated with three different lengths (3, 10, and 20 identical CTPR units) and optimized varied synthetic conditions. These findings revealed higher doping rate and oxidized state of the PEDOT chains when doped with the smallest scaffold (CTPR3). These PEDOT:CTPR hybrids possess ionic and electronic conductivity. Notably, PEDOT:CTPR3 displayed an electronic conductivity of 0.016 S cm-1, higher than any other reported protein-doped PEDOT. This result places PEDOT:CTPR3 at the level of PEDOT-biopolymer hybrids, and brings it closer in performance to PEDOT:PSS gold standard. Furthermore, PEDOT:CTPR3 dispersion is successfully optimized for inkjet printing, preserving its electroactivity properties after printing. This approach opens the door to the use of these novel hybrids for bioelectronics. This study showcases the synthesis of Poly(3,4-ethylenedioxythiophene) (PEDOT) dispersions doped with consensus tetratricopeptide repeated proteins (CTPR) via oxidative polymerization. Notably, PEDOT:CTPR demonstrates electroactivity and mixed ionic-electronic conduction. Particularly, PEDOT:CTPR3 exhibits the highest doping rate and electronic conductivity at 0.016 S cm-1, akin to PEDOT:PSS. Moreover, PEDOT:CTPR3 presents superior biocompatibility with NIH3T3 fibroblast cells and precise inkjet printability.image
更多
查看译文
关键词
bioelectronics,conductive biomaterials,consensus tetratricopeptide repeat (CTPR),engineered proteins,inkjet printing,mixed conductors,PEDOT,self-assembly
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要