SMYD3 Activates the TCA Cycle to Promote M1-M2 Conversion in Macrophages

Wenqiang Zhu,Lina Liu, Jinjing Wu, Renzhuo Gao, Liying Fu,Xiaohong Yang,Yang Zou,Shuhua Zhang,Daya Luo

INTERNATIONAL IMMUNOPHARMACOLOGY（2024）

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摘要

•Histone methyltransferase SMYD3 promotes M1-M2 conversion of macrophages.•SMYD3 activates the TCA cycle in macrophages.•Citrate promotes ROS production to induce M1-M2 conversion by mitophagy.

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关键词

SMYD3,Histone modification,TCA cycle,Mitophagy,Macrophage phenotype conversion

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