Radiomitigation Properties of α-Lipoic Acid when Used alone and in Combination with Metformin or Ethylmethylhydroxypyridine Succinate (Mexidol) in Mice after Exposure to X-ray Radiation

The radiomitigatory properties of α-lipoic acid and its use in combination with metformin and mexidol (ethylmethylhydroxypyridine succinate) in acute X-ray irradiation of animals have been studied. The study of radiation damage to the DNA of polychromatophilic erythrocytes of the red bone marrow of mice using a micronuclear test showed that α-lipoic acid had genoprotective and radiomitigatory properties in vivo. A study of the 30-day survival rate of mice exposed to a lethal dose confirmed that α-lipoic acid have radiomitigatory properties. The radiomitigatory effect of α-lipoic acid was concentration-dependent, and low doses of the drug were most effective. The radiomitigatory properties of α-lipoic acid were reduced in combination with mexidol and metformin.