Supplementary Figures S1-9, Tables S1 and 2 from Targeting the MDM2/MDM4 Interaction Interface As a Promising Approach for P53 Reactivation Therapy

Supplementary Figures S1-9, Tables S1 and 2. Supplementary Figure S1: Analysis of p53 ubiquitination and binding Supplementary Figure S2: Pep3 activity in human tumor cell lines Supplementary Figure S3: Pep3 activity in untransformed cells Supplementary Figure S4: In vivo Pep3 activity Supplementary Figure S5: Pep3 molecular activity Supplementary Figure S6: Transcriptomic analysis of Pep3 Supplementary Figure S7: Pep3 activity on p53 transcriptional function Supplementary Figure S8: Analysis of BIK and PIG3 knockdown Supplementary Figure S9: Analysis of Pep3-mediated pro-oxidant activity Supplementary Table S1: List of genes differentially expressed between Pep3- and Pep3M- treated HCT116 at 24hrs Supplementary Table S2: List of genes differentially expressed between Pep3- and Pep3M- treated HCT116 at 48hrs