Pathology, Pathogenesis, Clinical Features, and Diagnosis

Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system, which can be classified as intrahepatic, perihilar, and distal. Each anatomic subtype has distinct genetic aberrations, clinical presentations, and therapeutic approaches. In this chapter, a comprehensive review of pathology, pathogenesis, clinical features, and diagnostic approach of CCA will be provided and discussed.