The effect of the immune checkpoint inhibitor anti-LAG-3 on antigen-specific T-cells compared with nivolumab in vitro in head and neck cancer

Klara Six, Carlotta Kaißer, Marlies Götz,Jochen Greiner,Marie‐Nicole Theodoraki, v.Witzleben Adrian,Simon Laban,Cornelia Brunner,ThomasK. Hoffmann,PatrickJ. Schuler

Laryngo-rhino-otologie（2023）

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摘要

Background In head and neck squamous cell carcinoma (HNSCC), the response rate for anti-PD-1 checkpoint inhibitors (CPI) is approximately 20%, highlighting the need for the search for additional immune-based therapeutic options. In addition, the impact of CPI on antigen-specific T-cells is not well understood and should be further investigated.

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关键词

immune checkpoint inhibitor,cancer,anti-lag,antigen-specific,t-cells

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