Median effective does of Ciprofol combined with sufentanil for inhibiting the upper gastrointestinal endoscopic placement reaction

Objective: Ciprofol combined with sufentanil was used to explore median effective dose and 95% confidence interval for inhibiting the upper gastrointestinal endoscopic insertion response in elderly patients using up-and-down sequential allocation trial, provide a reference for clinical rational drug use. Methods: We studied fifty-seven patients who were scheduled to undergo a diagnostic upper gastrointestinal endoscopy. According to age, it is divided into two groups: 65~74 years old and over 75 years old. Using the modified Dixon sequence test method, intravenous bolus of 0.1 μg/kg sufentanil is given after 3 min before ciprofol is administered, the initial dose of ciprofol is 0.4 mg/kg, the upper gastrointestinal endoscopy is placed after reaching the depth of sedation. Results: In the group A, when combined with 0.1 sufentanil, the ED of ciprofol to inhibiting responses to insertion of upper gastrointestinal endoscopy was 0.23 mg/kg， and the 95% CI was 0.09~0.30 mg/kg; in the group B, the ED was 0.18mg/kg，and the 95% CI was 0.13~0.22mg/kg. Conclusion: The ED of ciprofol in combination with sufentanil (0.1 μg/kg) for upper gastrointestinal endoscopy in elderly patients: 0.23 mg/kg in group A, 0.18 mg/kg in group B.