Ab1167 prevalence of obesity and evaluation of the waist circumference in patients with rheumatoid arthritis and psoriatic arthritis in a hospital.

Background Obesity is a condition characterized by a chronic state of low-grade inflammation due to increased cytokine production in visceral adipose tissue [1].Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PSA) are both autoimmune diseases that share comorbidities such as a high prevalence of obesity, a comorbidity that leads to a lower response to treatment with biologic drugs such as Anti-TNFs [2]. PSA has a higher prevalence of abdominal obesity to RA according to some recent studies [3]. Current research has shown that excess adiposity contributes to the development of cutaneous psoriasis in some patients and suggests that obesity may also be a key factor in the transition from cutaneous psoriasis to arthritis [4], however, it has not been proven the etiological role of obesity in RA [5]. Objectives To evaluate the waist circumference (WC) and the prevalence of obesity using the Body Mass Index (BMI) in a sample patients from the same hospital with a diagnosis of RA and PSA and to analyze the differences between both diseases. Methods It has been carried out an observational, retrospective, single center study. The population included in the study were patients from rheumatology clinic with a diagnosis of RA and PSA who were being treated with biological treatment. The variables analyzed were: age, sex, height (m), body mass (Kg) and WC (cm). The anthropometric variables were measured in the rheumatology nursing clinic. An anthropometric tape was used to measure the WC, taking the height of the navel as a reference in the patients. The BMI was calculated and the World Health Organization classification was used to categorize the patients. A descriptive analysis of the variables analyzed in the study was performed, including the mean and standard deviation (SD) of the continuous quantitative variables (BMI and WC). A one-factor ANOVA was performed to analyze the differences in the variables age, BMI, and WC between RA and PSA patients. Statistical significance was set a priori at p<0.05. Results In this study a total of 245 RA and 122 PSA patients were included. The WC and BMI data of only 207 patients (121 with RA and 86 with PSA) were completed. The patients with PSA showed higher values of WC, observing significant differences with the patients with RA (103.66±15.05 cm vs 99.38±14.90 cm, p=0.04). However both patients with PSA and with RA showed WC measurements above the recommended values (74.41% vs 74.38%). Regarding BMI, patients with PSA had a higher mean BMI (31.29±6.37 cm vs 28.85±5.84 cm, p<0.043) than patients with RA. Conclusion In the present study, patients with PSA showed stadistical differences and had higher values of WC and BMI compared to patients with RA, coinciding with recent studies. More studies are necesary to characterize obesity in patiens wih RA and PSA and treat it adequately. References [1]Moroni L, Farina#8232;N et al. Obesity and its role in the management of rheumatoid and psoriatic arthritis. Clinical Rheumatology(2020)39:1039–1047 [2]Lyn D. Ferguson et al. Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank.Rheumatology 2019;58:2137 2142 doi:10.1093/rheumatology/kez192 [3]Li B, Huang H. Discrepancy in Metabolic Syndrome between Psoriatic Arthritis and Rheumatoid Arthritis: a Direct Comparison of Two Cohorts in One Center. Rheumatol Ther https://doi.org/10.1007/s40744-022-00502-4 [4]Ramírez K, Azuaga-Piñango AB et al. Update on Cardiovascular Risk and Obesity in Psoriatic Arthritis. Article 742713. Oct 2021. [5]Ulrich H, Häupl T et al.The etiology of rheumatoid arthritis.Journal of Autoimmunity 110 (2020) 102400. Acknowledgements: NIL. Disclosure of Interests None Declared.