Synthesis of Nirmatrelvir: Design and Optimization of an Efficient Telescoped Amidation–Dehydration Sequence
Russell F. Algera,Aaron F. Baldwin,Paul Bowles,Hugh J. Clarke,Christina G. Connor,Eric M. Cordi,Nga M. Do, Lindsay D. Nicholson, William Georgian, Alan Happe, Madeline I. Herman, Elaa Hilou, Chintelle James,Amber M. Johnson, Maciej Kalinowski,Samir A. Kulkarni, Katherine D. Launer-Felty,Johnny W. Lee,Taegyo Lee, Jorge Lopez,Emma L. Mcinturff,Jared L. Piper,David W. Place,John A. Ragan, Blake Rauschenberger, Katherine Ryder,Michael Stanley,Gerald A. Weisenburger,R. Matthew Weekly,Christophe Allais ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）
Key words
amide bond formation,dehydration,telescopedprocess,process optimization
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