OA03.04 A Phase 1b Study of Furmonertinib, an Oral, Brain Penetrant, Selective EGFR Inhibitor, in Patients with Advanced NSCLC with EGFR Exon 20 Insertions
Journal of Thoracic Oncology(2023)
摘要
Epidermal growth factor receptor (EGFR) Exon 20 insertion (Exon20ins) mutations constitute approximately 9% of all the EGFR mutations (Robichaux et al. 2021) in non-small cell lung cancer (NSCLC). Furmonertinib is an oral, brain penetrant, EGFR tyrosine kinase inhibitor (TKI) engineered for broad activity and selectivity across EGFR mutations including Exon20ins (Musib et al., NACLC 2022). Furmonertinib is being studied in an ongoing phase 1b clinical trial in NSCLC patients with EGFR Exon20ins mutations (FAVOUR; NCT04858958).
更多查看译文
关键词
EGFR Mutations,EGFR Inhibitors
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要