FIGURE 2 from Immune Cell Abundance and T-cell Receptor Landscapes Suggest New Patient Stratification Strategies in Head and Neck Squamous Cell Carcinoma

Genomic processes in the HNSCC cohort. A, Driver genes recurrently altered (by SNV/indel) in more than 10% of the samples are shown, along with key clinical (HPV status, stage) and molecular characteristics (immunity subgroup). The bar plots display the total number of mutations per gene (rows) and sample (columns), respectively, across the cohort. B, The pattern of mutational probabilities for the 96 base substitution contexts characterizing the mutational signatures SBS2 and SBS13, showing distinct prevalence across immunity subgroups, is displayed. C, The SBS signatures associated with mutational processes 2 and 13 from the COSMIC database, linked with AID/APOBEC activity, show differing contributions of mutations by immunity subgroup, with an increase in the PC rich subgroup (boxplot subgroup colors as in A). **, P < 0.01; *, P < 0.05; ns, nonsignificant (P > 0.05).