Paget's Disease of Bone: a Single Center Experience

Abstract Introduction Paget's disease of bone, osteitis deformans is a benign disease of bone that affects one or more bones. Its prevalence and clinical features show geographical region differences. In this study, it was aimed to investigate the treatment responses and follow-up results as a single center experience by using the demographic, clinical, laboratory and radiological characteristics of patients with Paget's Disease of the Bone. Method Fifty one patients who were diagnosed and followed up in Aydın Adnan Menderes University Endocrinology clinic between September 2004 and December 2021 were included in the study retrospectively. Results The mean age of onset of the disease was 61.8±12.5 years and the mean follow-up period was 9.3±8.2 years. It was observed that 68.63% of the patients were asymptomatic. Polyostotic involvement is present in 62.7% of the patients. It was observed that the disease most commonly involved the pelvis. It was determined that alkaline phosphatase value was above the upper reference limit in all patients at the time of diagnosis. All patients have increased activity in whole body bone scintigraphy. Except for one patient, all patients received bisphosphonate therapy. Remission was achieved in all patients who received zolendronic acid treatment as the first treatment. Since there was no response in the treatment of 8 patients receiving oral bisphosphonate and 2 patients receiving pamidronate, IV zolendronic acid treatment was started. Treatment response was achieved in 6 (75%) of 8 patients who did not go into remission with oral bisphosphonate, and in 1 (50%) of 2 patients who received pamidronate and did not go into remission, after switching to zolendronic acid, and serum alkaline phosphatase values were found to regress to the normal range. Conclusion In this study, it was determined that patients with asymptomatic alkaline phosphatase elevation should also be examined for Paget's disease of the bone and that zolendronic acid provides an effective treatment in Paget's disease of the bone.