Study the correlation of eosinophils, serum IL-33, total IgE and specific IgE with childhood asthma

Analyze the expression levels of total IgE, eosinophils, and serum IL-33 in asthmatic and healthy children, and analyze the distribution characteristics of specific IgE in children with asthma.197 children with asthma who attended the clinic between October 2021 and October 2022, as well as 117 healthy children who participated in the clinical examination during the same period were randomly chosen. The distribution of total IgE, eosinophils and serum IL-33 were detected, and ROC curves were drawn to analyze their diagnosis value of childhood asthma. Besides, the characteristics of specific IgE distribution in the 197 children with asthma were also analyzed. The expression level of total IgE, eosinophils and IL-33 were significantly higher in asthmatic children than in healthy children. The analysis of specific IgE indicated that the allergen positive rate of children with asthma was 88.32%, among which 79.42% were multi-allergic. The top three allergens were: mold (48.22%), dermatophagoides pteronyssinus (44.67%), and dermatophagoides farinae and milk (32.99%).Besides, the positive rate for inhalant allergens was 78.17%, and it was 57.36% for food allergens. Results showed that the total IgE, eosinophil percentage, eosinophil and serum IL-33 count were all significantly higher in children with asthma than those in healthy children. Analysis of ROC curves indicated that total IgE, eosinophil count, eosinophil percentage and serum IL-33 were helpful for the diagnosis of asthma. However, no significant differences in total IgE and blood eosinophils were observed between typical asthma and cough allergic asthma. Moreover, the allergy rate and the percentage of multiple allergies were high in children with asthma, and the positive rate of inhalant allergens was higher than that of food allergens. Besides, molds, dermatophagoides pteronyssinuss and dermatophagoides farinae were the most three common allergens in children with asthma, and the positive rate of typical asthma allergens was higher than that of cough variant asthma.This manuscript reflects our findings that Diagnostic value of the total IgE, eosinophils and serum IL-33 in childhood asthma.Besides，we analyze the distribution of allergens in children in Yangzhou, China.We thereby believe that the data contained in our manuscript are of importance and will be of interest to the wide readership of World children asthma.