Abstract P2010: Relationship Between Echocardiographic Parameters and Invasively Measured Left Ventricular Filling Pressure in the Persistent Atrial Fibrillation with Preserved Left Ventricular Systolic Function

CIRCULATION RESEARCH（2023）

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Abstract

Background: Among patients with normal systolic function, elevated left ventricular end diastolic pressure (LVEDP) could represent early diastolic dysfunction or could be the main physiological consequence of diastolic dysfunction. However, the evaluation of LVEDP using classic echocardiographic assessment has been challenging in the setting of atrial fibrillation (AF). The aim of this study was to investigate the methods for predicting LVEPD in patients with persistent AF. Methods: Clinical data, laboratory data, and echocardiography findings were assessed in 90 patients with chronic AF who were undergoing diagnostic left-heart catheterization. LVEDP and standard echocardiographic measurements including pulmonary arterial systolic pressure (PASP) were evaluated. Results: E/e’ (r=0.448, p<0.001), E/Vp (r=0.471, p<0.001) and PASP (r=0.421, p<0.001) correlated well with LVEDP (figure 1). Using receiver operating characteristic analysis, the optimal cut-off for E/e’ was 13 (sensitivity, 88%; specificity, 65%) to predict LVEDP of >15 mmHg (figure ). Conclusion: E/e’, E/Vp and PASP were well correlated with LVEDP in patients with AF with preserved EF. E/e’ greater than 13 may suggest elevated LVEDP (>15 mmHg) in patients with persistent AF.

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Key words

Atrial fibrillation,Pressure - volume relation,Heart failure

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【要点】：该研究探讨了在持续性心房颤动且左室收缩功能保留的患者中，通过超声心动图参数预测左室舒张末期压力（LVEDP）的方法，发现E/e'、E/Vp和肺动脉收缩压（PASP）与LVEDP具有良好的相关性。

【方法】：研究通过分析90例慢性心房颤动患者进行左心导管检查的临床、实验室和超声心动图数据，评估了LVEDP与E/e'、E/Vp和PASP的关系。

【实验】：实验使用了90例慢性心房颤动患者的数据，进行了相关性分析和接受者操作特征（ROC）分析，确定E/e'大于13为预测LVEDP大于15 mmHg的最佳截断值。