Abstract P3011: Assessing Subclinical Atherosclerosis Using Carotid Intima-media Thickness in Inflammatory Bowel Disease Patients: A Metanalysis

Objective: Chronic inflammatory diseases are linked to atherosclerosis and cardiovascular events. However, there are conflicting results published in the literature regarding differences in carotid intima-media thickness, a marker of subclinical atherosclerosis, between inflammatory bowel disease patients and controls. We aimed to conduct a pooled analysis of the studies and determine if it is true. Method: We performed a systematic literature search of databases Google Scholar, Scopus and PubMed from Jan 01, 2012, until Feb 01, 2023. Unadjusted odds ratios (OR) were pooled using a random-effect model, and a p-value of <0.05 was considered statistically significant. Findings: A total of 4 studies with 354 participants were shortlisted for analysis. The results shown in the figure show an insignificant difference in the carotid intima-media thickness between inflammatory bowel disease patients and control groups of healthy individuals - the odds ratio came out -0.22 with a confidence interval of -0.89 to 0.45 and p-value of <0.05. Conclusions: Our pooled analysis revealed no impact of IBD on carotid-intima media thickness. Future studies should focus on scrutinizing the actual risk of atherosclerosis and its complications with the disease.