Inwardly Rectifying Potassium Channels (k<sub>ir</sub>) in GtoPdb V.2023.1

John P. Adelman,David E. Clapham,Hiroshi Hibino,Atsushi Inanobe, Yuh Nung Jan,Andreas Karschin,Yoshihiro Kubo,Yoshihisa Kurachi,Michel Lazdunski,Takashi Miki,Colin G. Nichols,Lawrence G. Palmer,Wade L. Pearson,Henry Sackin,Susumu Seino,Paul A. Slesinger,Stephen J. Tucker,Carol A. Vandenberg

IUPHAR/BPS guide to pharmacology CITE（2023）

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摘要

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

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Inwardly Rectifying Potassium Channels (k&lt;sub&gt;ir&lt;/sub&gt;) in GtoPdb V.2023.1

Inwardly Rectifying Potassium Channels (k<sub>ir</sub>) in GtoPdb V.2023.1