Hydrosalpinx: interstitial pregnancy following ipsilateral salpingectomy risk factor? a case-control study with propensity score matching.

Abstract To identify risk factors associated with interstitial pregnancy following ipsilateral salpingectomy and discuss possible prevention.A retrospective cohort study was conducted in a single, large, university-affiliated hospital. Data of 29 patients diagnosed with interstitial pregnancy following ipsilateral salpingectomy from January 2011 to November 2020 were assigned into the case group (IP group), whereas 87 patients derived from 6151 patients with intrauterine pregnancy following unilateral salpingectomy were served as the controls using propensity score matching (PSM) at a ratio of 1:3. After PSM, there was no statistically significant difference in patient demographic details between the two groups . The multipara was greater and the intrauterine operation was more frequent in the IP group compared with the control group (P＜0.05). There was only one patient undergoing IVF-ET in the IP group as compared with 29 cases in the control group (3.4% vs. 33.3%, P＜0.05). Salpingectomy was performed on 5 patients in the IP group and 4 patients in the control group due to hydrosalpinx (P＜0.05). Logistic regression indicated that hydrosalpinx was the high risk factor of interstitial pregnancy following ipsilateral salpingectomy (OR=8.175).Our PSM analysis suggests that hydrosalpinx has significantassociation with risk of interstitial pregnancy following ipsilateral salpingectomy in subsequent pregnancy.