One Fell Swoop: Addressing Combined Aortic Stenosis and Regurgitation with TAVR

Though most patients undergoing transcatheter aortic valve replacement (TAVR) have some degree of aortic regurgitation (AR), outcomes are not clearly defined in those with concomitant severe stenosis and moderate or greater AR (AS+AR). In this issue of The Annals of Thoracic Surgery, Yousef and colleagues 1 Yousef S. Bianco V. Kliner D. et al. Outcomes of transcatheter aortic valve replacement in patients with concomitant aortic regurgitation. Ann Thorac Surg. 2023; 116: 728-735 Abstract Full Text Full Text PDF Scopus (1) Google Scholar present outcomes from a single healthcare system in patients with AS+AR compared with isolated AS; AR less than moderate were excluded. Despite mixed pathology, mortality and complications were similar between cohorts, as were post-TAVR valve gradients and paravalvular leak rates. The authors postulated AS+AR may compromise left ventricular (LV) recovery and seemed to expect worse outcomes. However, on multivariable Cox regression, AS+AR was not associated with an increased hazard of death. Outcomes of Transcatheter Aortic Valve Replacement in Patients With Concomitant Aortic RegurgitationThe Annals of Thoracic SurgeryVol. 116Issue 4PreviewThis study sought to evaluate outcomes of transcatheter aortic valve replacement (TAVR) in patients with moderate or greater aortic regurgitation (AR). Full-Text PDF