The Safety and Efficacy of Direct Oral Anticoagulant Resumption Following a Gastrointestinal Bleeding Episode: A Systematic Review and Meta-Analysis

Aims The number of patients treated with direct oral anticoagulants (DOACs) has rapidly elevated in the last decade. Compared to Vitamin-K antagonists, DOACs have a better safety profile, except for gastrointestinal bleeding (GIB). After successfully managing GIB, a therapy reintroduction decision must be made carefully, although data addressing this topic is lacking. We aim to determine the safety and efficacy of DOACs resumption after GIB.