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    • Supplementary Figure Legend from Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia

    openalex（2023）

    Cited 0|Views30
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    Ibrutinib
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
    • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
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    【要点】：该论文探讨了在慢性淋巴细胞性白血病（CLL）中，降低NOTCH1激活与对伊布替尼响应之间的相关性，创新性地提出伊布替尼可能通过调节NOTCH1信号通路影响CLL细胞的生存。
    

    【方法】：研究人员通过流式细胞术和免疫组化分析评估了CLL细胞中NOTCH1激活水平，并使用了伊布替尼进行干预研究。
    

    【实验】：实验结果显示，在使用伊布替尼治疗的CLL患者中，那些NOTCH1激活水平降低的患者表现出更好的治疗响应。数据集名称未在摘要中提及，但实验结果被用来建立NOTCH1激活与伊布替尼疗效之间的联系。