Gastric Cancer in the Next-Generation Sequencing Era: Diagnostic and Therapeutic Strategies
IntechOpen eBooks(2023)
摘要
Gastric cancer (GC) is one of the most common malignancies and the fourth major cause of cancer-related deaths worldwide. There is growing interest in the role of genetic and epigenetic changes in the development of the disease. Next-generation sequencing (NGS) studies have identified candidate cancer-driving genes in the GC. Whole transcriptome sequencing and whole-genome sequencing analysis is also important methodology in discovering novel changes in GC. Importantly, cancer epigenetics has opened the way to reveal cancer-related genes in epigenetic machinery, including DNA methylation, nucleosome positioning, noncoding RNAs, and microRNAs, as well as histone modifications. The latest molecular research on GC may be a new diagnostic and therapeutic strategy in clinical practice. In this review, we will focus on recent advances in the description of the molecular pathogenesis of gastric cancer, underlying the use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets.
更多查看译文
关键词
gastric cancer,next-generation
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要