The genetic communication and interaction between chronic kidney diseases and frailty

The prevalence of chronic kidney disease (CKD) is increasing due to the global ageing trend. Despite significant advancements in understanding the mechanisms of CKD, little research has focused on the prevention and treatment of associated complications such as frailty. In this review, we provide a summary of the current Genome-Wide Association Studies (GWAS) of kidney diseases based on the unique genetic characteristics of kidneys and a review of the impact of metabolites associated with inflammageing on frailty and CKD. Additionally, the role of circadian rhythm in the intrinsic relationship between kidney and skeletal muscle has also been explored. This article offers insights into the potential communications and interactions between CKD and frailty to facilitate the current clinical treatments and improve the life quality for frail elderly individuals in coexistence of CKD. The heritability of kidney affects the risk of chronic kidney disease and frailty.Inflammageing-related metabolites, including tryptophan, taurine, carnitine and sphingolipids, link chronic kidney disease and frailty.Circadian rhythm disorders may play a key role in the interaction between chronic kidney disease and frailty. image