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Efficacy of Oral 20-Hydroxyecdysone (BIO101), a MAS Receptor Activator, in Adults with Severe COVID-19 (COVA): a Randomized, Placebo-Controlled, Phase 2/3 Trial

Suzana Margareth Lobo,Gaetan Plantefeve,Girish Nair,Adilson Joaquim Cavalcante,Nara Franzin de Moraes, Estevao Nunes, Otis Barnum, Claudio Marcel Berdun Stadnik, Maria Patelli Lima, Muriel Lins,Ludhmila Abrahao Hajjar, Christopher Lipinski,Shaheen Islam, Fabiano Ramos, Tiago Simon, Jean-Benoit Martinoti,Thomas Guimard,Arnaud Desclaux,Bertrand Lioger,Fernando Carvalho Neuenschwander, Bruno DeSouza Paolino,Alpesh Amin, Samuel Amil Acosta,Daniel Forde Dilling, Edgardo Cartagena, Brian Snyder,Edouard Devaud, Ana Karolina Barreto Berselli Marinho, Suzana Tanni, Patricia Medeiros Milhomem Beato, Stephan Dewit, Vani Selvan, Jeffrey Gray, Ricardo Fernandez, Valerie Pourcher, Lee Maddox,Richard Kay, Anait Azbekyan, Mounia Chabane,Cendrine Tourette, Luis Everton Esmeraldino,Pierre J. Dilda,Rene Lafont,Jean Mariani,Serge Camelo, Sandrine Rabut,Samuel Agus,Stanislas Veillet,Waly Dioh,Rob van Maanen,Capucine Morelot-Panzini

ECLINICALMEDICINE(2024)

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关键词
SARS-CoV-2,COVID-19,Renin-angiotensin-system (RAS),MasR,20-Hydroxyecdysone,Respiratory failure
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