Electrospun biotin- and streptavidin-coated quartz crystal microbalance surfaces: characterization and mass sensing performance using OpenQCM

Abstract In this study, a quartz crystal microbalance (QCM) sensor surface was coated with biotin and/or streptavidin using the electrospinning method. The coated surfaces were analyzed using the Raman spectroscopy method. QCM measurements were carried out using the OpenQCM platform. The results indicate that the electrospinning method can be used to coat QCM surfaces with biotin and/or streptavidin and that the coated surfaces exhibit distinct morphological and spectroscopic properties. The QCM measurements showed that the coated surfaces are highly sensitive to changes in mass, indicating their potential for use in biosensing applications. Overall, this study provides new insights into the use of QCM sensors coated with biotin and/or streptavidin for biological sensing and detection applications.