Supplemental Figure S4 from RAF-Mutant Melanomas Differentially Depend on ERK2 over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

Matthew S. Crowe,Tatiana Zavorotinskaya,Charles F. Voliva, Matthew D. Shirley, Yanqun Wang,David A. Ruddy,Daniel P. Rakiec, Jeffery A. Engelman,Darrin D. Stuart,Alyson K. Freeman

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摘要

Supplementary Figure S4 shows Western blot analysis and dose-response effects of ERK inhibition in A375 cells expressing inhibitor-resistant ERK2 with or without additional mutations affecting kinase activity or substrate docking.

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MEK Inhibition

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