Supplementary Methods, Figure Legends, Table Legends, Table S1, Tables S3 - S4 from Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

Youngtae Jeong, Ngoc T. Hoang,Alexander Lovejoy,Henning Stehr,Aaron M. Newman,Andrew J. Gentles,William Kong,Diana Truong,Shanique Martin,Aadel Chaudhuri,Diane Heiser,Li Zhou,Carmen Say,Justin N. Carter,Susan M. Hiniker,Billy W. Loo,Robert B. West,Philip Beachy,Ash A. Alizadeh,Maximilian Diehn

openalex（2023）

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Abstract

Supplementary Table S1. In vivo limiting dilution analyses of P-LSCC and K/P-LSCC. Supplementary Table S3. Likely zygosity and functional effects of KEAP1 mutations in NSCLC patients in Fig. 7A. Supplementary Table S4. Clinical characteristics of a validation cohort of stage I-III NSCLC patients treated with curative intent RT and analyzed for KEAP1/NRF2 mutation status using targeted next generation sequencing. Antibodies used in this study.

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EGFR Mutations

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【要点】：本文研究了KEAP1/NRF2和TP53突变在肺鳞状细胞癌发展及放射抵抗中的作用，发现这些基因的突变与肿瘤的发展和放疗敏感性有关。

【方法】：通过靶向下一代测序技术分析患者肿瘤样本中的KEAP1、NRF2和TP53基因突变情况，并结合临床数据进行相关性分析。

【实验】：进行了体内限制稀释分析，使用的数据集包括P-LSCC和K/P-LSCC，以及针对NSCLC患者的KEAP1突变功能效应和临床特征分析，实验结果在补充表格S1、S3和S4中展示。

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