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    • Figure S3 from COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin

    Fuli Wang, Hongyong Zhang, Ai-Hong Ma,Weimin Yu,Maike Zimmermann, Jun Yang,Sung Hee Hwang,Daniel Zhu, Tzu-yin Lin,Michael Malfatti,Kenneth W. Turteltaub, Paul T. Henderson,Susan Airhart, Bruce D. Hammock,Jianlin Yuan,Ralph W. de Vere White,Chong-Xian Pan

    openalex（2023）

    Cited 0|Views1
    Abstract
    Body weight change during PDX bladder cancer mice experiment
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    Tumor Microenvironment
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    【要点】：本文研究了COX-2/sEH双抑制剂PTUPB与顺铂联合使用，在PDX膀胱癌小鼠模型中增强抗肿瘤效果，并观察了体重变化。
    

    【方法】：通过分子对接和细胞实验分析PTUPB与COX-2和sEH的相互作用，以及其在体外对癌细胞生长的影响。
    

    【实验】：在PDX膀胱癌小鼠模型中，实验组接受PTUPB与顺铂联合治疗，对照组仅接受顺铂治疗，通过监测小鼠体重变化评估治疗效果，使用的数据集为PDX膀胱癌小鼠实验数据，结果显示联合治疗显著提高了抗肿瘤效果。
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