Ibulocydine Inhibits Migration and Invasion of TNBC Cells via MMP-9 Regulation

Mi-Ri Kwon, Ji-Soo Park, Eun-Jung Ko, Jin Park,Eun-Jin Ju, Seol-Hwa Shin, Ga-Won Son,Hye-Won Lee, Yun-Yong Park,Myoung-Hee Kang, Yeon-Joo Kim,Byeong-Moon Kim, Hee-Jin Lee, Tae-Won Kim, Chong-Jai Kim,Si-Yeol Song, Seok-Soon Park,Seong-Yun Jeong

International Journal of Molecular Sciences(2024)

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摘要
Triple-negative breast cancer (TNBC) accounts for approximately 15–20% of all breast cancer types, indicating a poor survival prognosis with a more aggressive biology of metastasis to the lung and a short response duration to available therapies. Ibulocydine (IB) is a novel (cyclin-dependent kinase) CDK7/9 inhibitor prodrug displaying potent anti-cancer effects against various cancer cell types. We performed in vitro and in vivo experiments to determine whether IB inhibits metastasis and eventually overcomes the poor drug response in TNBC. The result showed that IB inhibited the growth of TNBC cells by inducing caspase-mediated apoptosis and blocking metastasis by reducing MMP-9 expression in vitro. Concurrently, in vivo experiments using the metastasis model showed that IB inhibited metastasis of MDA-MB-231-Luc cells to the lung. Collectively, these results demonstrate that IB inhibited the growth of TNBC cells and blocked metastasis by regulating MMP-9 expression, suggesting a novel therapeutic agent for metastatic TNBC.
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tnbc cells
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