Supplementary Figure S6 from in Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 As a Therapeutic Target

Ana Vujovic,Laura de Rooij， Gene W. Yeo,Kristin J. Hope

openalex（2023）

Cited 0|Views1

Abstract

Supplemental Figure S6 shows the GSEA of ELAVL1 depletion in mouse RN2c and human primary AML cells, ELAVL1 subcellular localization in mouse and human AML, the qRT-PCR of ELAVL1 targets in MS-444-treated RN2c cells, and the integrative analysis of the mouse RNA-seq and eCLIP-seq.

Translated text

Key words

Leukemia Stem Cells,Molecular Response

Bibtex

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Data Disclaimer

The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn

Chat Paper

【要点】：本研究通过在体筛选发现白血病干细胞中普遍存在的RNA结合蛋白依赖性，并确定ELAVL1为治疗靶点。

【方法】：使用基因集富集分析（GSEA）和定量RT-PCR等方法，结合RNA-seq和eCLIP-seq数据进行分析。

【实验】：实验在mouse RN2c和人类原代AML细胞中进行，使用MS-444处理RN2c细胞，并进行小鼠的RNA-seq和eCLIP-seq综合分析。

去 AI 文献库对话