Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex

Beth Mann,Jeremy Chase Crawford,K. Kishta Reddy,Josi Lott,Yong Ha Youn,Geli Gao,Cliff Guy,Ching‐Heng Chou,Daniel Darnell,Sanchit Trivedi,Perrine Bomme,Allister J. Loughran,Paul G. Thomas,Young-Goo Han,Elaine Tuomanen

MBio（2023）

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摘要

Fetal brain development in early gestation can be impacted by transplacental infection, altered metabolites from the maternal microbiome, or maternal immune activation. It is less well understood how maternal microbial subcomponents that cross the placenta, such as bacterial cell wall (BCW), directly interact with fetal neural progenitors and neurons and affect development.

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derepress hedgehog signaling,neocortex

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