Liver-Humanized NSG-PiZ Mice Support the Study of Chronic Hepatitis B Virus Infection and Antiviral Therapies

Rossana Colón-Thillet,Daniel Stone,Michelle A. Loprieno,Lindsay M. Klouser,Pavitra Roychoudhury,Tracy K. Santo,Hong Xie,Laurence Stensland,Sarah Upham,Gregory Pepper,Meei‐Li Huang,Martine Aubert,Keith R. Jerome

Microbiology spectrum（2023）

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摘要

Liver-humanized mouse models have become the gold standard for the in vivo study of hepatitis B virus (HBV), yet their complexity and cost have prohibited widespread use of existing models in research. Here, we show that the NSG-PiZ liver-humanized mouse model, which is relatively inexpensive and simple to establish, can support chronic HBV infection.

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关键词

antiviral therapies,chronic hepatitis,liver-humanized,nsg-piz

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