Reduced DIO3OS expression in hepatocellular carcinoma predicts poor prognosis and is associated with tumor immunity

Abstract Hepatocellular carcinoma(HCC) has become one of the most shared cancers in the whole world because of its high morbidity, poor survival rate and low recovery rate. Especially in China, HCC has been regarded as one of the most malignant cancers. With the development of tumor exploration and treatment over the years, it has been found that lncRNA plays a direct or indirect regulatory role in the process of tumorigenesis and cancer development, which brought a new direction for early diagnosis and therapy. Previous studies had investigated that DIO3OS played a promoting role in the occurrence and development of thyroid carcinoma and uterine corpus endometrial carcinoma. However, research focusing on the role of DIO3OS in HCC is still uncleared. Our work found that there was a significant negative correlation between low DIO3OS levels and HCC. In addition, there was also a correlation between immune cells and their surface markers and DIO3OS expression in HCC. Our findings demonstrated that DIO3OS may be a potential prognostic biomarker involved in the process of HCC by regulating immune cell infiltration.