What is Missing Before Gastric Peroral Endoscopic Myotomy Can Go Mainstream for Treatment of Gastroparesis?

Gastroparesis is a complex and heterogeneous motility disorder of the stomach. It is highly prevalent and etiologies include diabetes, surgery, and autoimmune, among others. Gastroparesis is a frustrating disease to patients and treating physicians. Medical therapy is limited for the most part to antiemetics and prokinetics, with suboptimal efficacy and nontrivial risk profile.1