P-248 Real-world Outcomes of Triple-Class Exposed Multiple Myeloma Patients by Treatment Experience: the Assocaition of Prior Lines and Penta-Refractoriness with Progression-Free and Overall Survival

Introduction:Triple-class exposed (TCE) multiple myeloma (MM) patients who present with extramedullary disease (EMD) or high-risk cytogenetics can experience disproportionately poor outcomes.The current study sought to examine the real-world relationship between these disease attributes, treatment patterns, and future outcomes.Methods: Using two US electronic health record databases (COTA and Flatiron Health), MM patients ≥18