Contribution to the Study of Antibiotic Sensitivity of <i>streptococcus Pneumoniae</i> Strains in Spinal Cerebral Fluids in Bangui from 2017 to 2022

A prospective and analytical study was carried out from January 2017 to December 2022, at the National Laboratory of Clinical Biology and Public Health (LNBCSP) in Bangui.352 samples of cerebrospinal fluid (CSF) were confirmed out of 2065, coming from the four hospitals in Bangui.This study aimed to evaluate the evolution of antibiotic sensitivity to strains of Streptococcus pneumoniae.CSF had been collected from patients who presented with meningeal syndromes.Based on the leukocyte count (White blood cells ≥ 5 mm 3 ), an aliquot was transferred to trans-isolate medium and sent to the LNBCSP for confirmatory testing, culture and determination of antibiotic sensitivity.The antibiotic sensitivity of Streptococcus pneumoniae strains was tested according to the methods recommended by the Antibiogram Committee of the French Society of Microbiology.The data collected was entered into Excel 2010 to be analyzed with Epi Info 7.2.Ficher's exact test, chi 2 at the 5% threshold (p < 0.05) was used to compare proportions and analyze associations between variables.The average sensitivity rate to β-lactams was 74.43%.The sensitivity rate of Fluoroquinolones was 54.54%.That of levofloxacin was 87%.The average rate of sensitivity to β-lactams for the age group under 5 years old was 79.25%.That of fluoroquinolones was 52.59%.Levofloxacin had 90.37%.The average sensitivity rate to β-lactams for the age group over 5 years