S929 Herbal Medicine for Active Ulcerative Colitis: Systematic Review and Meta-Analysis

Introduction: According to the literature, In fl ammatory Bowel Disease (IBD) patients with opioid dependency have a threefold higher mortality risk than non-users. Some studies suggest the role of cannabis usageinIBDdue toitsanti-in fl ammatoryproperties. However,noliteratureindicatestheimpactofcannabisusageonopioid-dependentIBD.Usinganationalpropensity-matchedsample,weassessedinpatient hospital outcomes of opioid-dependent IBD patients with Cannabis Use Disorder (CUD) vs non-CUD. Methods: The Nationwide Inpatient Sample database (2019) was queried to identify opioid-dependent IBD in CUD vs non-CUD cohorts. A Pearson Chi-square test and Mann-Whitney U tests were used to compare categorical and continuous variables between propensity-matched cohorts. In-hospital complications were the primary outcome; Length-Of-Stay and hospital expenses were secondary. Results: Of all opioid-dependent IBD hospitalizations, age and sex-matched CUD and non-CUD cohorts were studied. Both groups had 995 patients and a median age of 37 and shared similar sociodemographiccharacteristics.